کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565334 | 1128056 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
No association between EGR gene family polymorphisms and schizophrenia in the Chinese population
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کلمات کلیدی
MDREGRGenetic association - ارتباط ژنتیکیSchizophrenia - اسکیزوفرنی یا شیزوفرنیLinkage disequilibrium - عدم تعادل پیوستگیCase–control study - مطالعه موردی شاهدearly growth response - پاسخ رشد اولیهSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدMultifactor dimensionality reduction - کاهش ابعاد چند فاکتور
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: No association between EGR gene family polymorphisms and schizophrenia in the Chinese population No association between EGR gene family polymorphisms and schizophrenia in the Chinese population](/preview/png/2565334.png)
چکیده انگلیسی
Early growth response (EGR) genes are thought to have a role in the pathogenesis of schizophrenia because of their conserved DNA binding domain and biologically activity in neuronal plasticity. This zinc-finger motif could influence gene post-translational modification and expression. The multigenetic association model, using markers in genes of similar or antagonistic biological effects within a signal pathway or gene family, might be more appropriate to this aspect of the schizophrenia hypothesis than the single gene strategy. In this study we investigated the role of EGR1, EGR2, EGR3 and EGR4 within the EGR family. Taqman technology was used to examine 12 single nucleotide polymorphisms (SNPs) covering these four genes in 2044 Chinese Han subjects. Case-control analyses were performed to detect association of these 4 genes with schizophrenia and multifactor dimensionality reduction (MDR) analysis was employed to examine their potential gene-gene interaction in schizophrenia. Neither allelic nor genotypic single-locus tests revealed any significant association between EGR1-4 and the risk of schizophrenia nor was any such association found with regard to interaction within EGR1-4 (pmin = 0.623, CV Consistency = 10/10). We concluded that although multiple candidate genes are involved in schizophrenogenic development, the EGR family may not play a major role in schizophrenia susceptibility in the Chinese Han population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 34, Issue 3, 16 April 2010, Pages 506-509
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 34, Issue 3, 16 April 2010, Pages 506-509
نویسندگان
Bao-cheng Liu, Jing Zhang, Lei Wang, Xing-wang Li, Yang Wang, Jue Ji, Feng-ping Yang, Chun-ling Wan, Ling-han Gao, Yi-feng Xu, Guo-yin Feng, Lin He, Xin-zhi Zhao, Guang He,