کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565437 1128058 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats
چکیده انگلیسی

Isolation rearing induces various cognitive abnormalities such as reversal learning deficits and reduced prepulse inhibition in rats. However, there are few reports in the literature on its effects on social and emotional functions. In the current study we aimed to address these issues and demonstrated that isolation rearing induced aggression and impaired social recognition, produced moderate anxiogenic effects in the elevated-plus maze, and resulted in hyperactivity in a novel open field. We also found NR2A, NR2B, PSD-95 and SAP-102 mRNA expression were significantly up-regulated in the hippocampus while NR2B was down-regulated in prefrontal cortex in response to isolation rearing. This study advances the use of social isolation as an animal model for studying etiological mechanisms of various neuropsychiatric disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 7, 1 October 2009, Pages 1173–1177
نویسندگان
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