کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565620 | 1128063 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression
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کلمات کلیدی
BD-IUnipolar major depressive disorderDWMHBipolar Disorder Type IDSM-IV-TRPVHWMHMDD95%CI - 95٪ CIχ2 - x2Chi-squared test - آزمون Chi-squaredwhite matter hyperintensities - ابررایانه ماده سفیدMajor depressive disorder - اختلال افسردگی عمدهbipolar disorder - اختلال دو قطبیMajor affective disorders - اختلالات عاطفی عمدهMRI - امآرآی یا تصویرسازی تشدید مغناطیسیMagnetic resonance images - تصاویر رزونانس مغناطیسیSuicide - خودکشی، خودکشی کردن، انتحارDiagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision - راهنمای تشخیصی و آماری اختلالات روانی، ویرایش چهارم، مرور متن95% confidence intervals - فاصله اطمینان 95٪odds ratio - نسبت شانس ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD = 15.2; Min./Max. = 19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH-the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 6, 1 August 2008, Pages 1501-1507
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 6, 1 August 2008, Pages 1501-1507
نویسندگان
Maurizio Pompili, Marco Innamorati, J. John Mann, Maria A. Oquendo, David Lester, Antonio Del Casale, Gianluca Serafini, Silvia Rigucci, Andrea Romano, Antonino Tamburello, Giovanni Manfredi, Eleonora De Pisa, Stefan Ehrlich, Giancarlo Giupponi,