کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565660 1128064 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Central or peripheral norepinephrine depletion enhances MK-801-induced plasma corticosterone level in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Central or peripheral norepinephrine depletion enhances MK-801-induced plasma corticosterone level in mice
چکیده انگلیسی

To investigate the involvement of central or peripheral catecholaminergic systems in the MK-801-induced increase in plasma corticosterone and interleukin-6 levels, we pretreated mice either intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) with 6-hydroxydopamine (6-OHDA) which depletes catecholamines. Pretreatment of animals with 6-OHDA (50 μg i.c.v. or 100 mg/kg i.p.) significantly enhanced the MK-801 (1 μg i.c.v.)-induced increase in plasma corticosterone level. On the other hand, pretreatment of mice with 6-OHDA (50 μg i.c.v. or 100 mg/kg i.p.) did not affect the MK-801 (1 μg i.c.v.)-induced increase in plasma IL-6 level. These results suggest that central and peripheral catecholaminergic systems are involved in the suppressive regulation of MK-801-induced plasma corticosterone level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 1, 1 February 2009, Pages 45–48
نویسندگان
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