کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565839 1128068 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of anti-depressants on olfactory sensitivity in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Effects of anti-depressants on olfactory sensitivity in mice
چکیده انگلیسی

Rationale and objectivesSome studies have underlined a decrease in olfactory sensitivity in patients suffering from depression. The present study aims to evaluate the effects of current anti-depressant drugs on the olfactory sensitivity in mice.Methods mice(N° = 22) were tested in a Y-maze with a choice between an odorant (butanol) or distilled water before and during 3 weeks of daily intra-peritoneal injection of either citalopram or clomipramine. Their performance was compared with those of a control group (N° = 11) injected with a saline solution.ResultsThe results showed a significant decrease in olfactory sensitivity with both anti-depressants during the three weeks of treatment.ConclusionThe antidepressant induced alteration in serotonin and/or noradrenaline transmission in the olfactory bulb may account for the altered olfactory sensitivity observed in this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 3, 1 April 2008, Pages 629–632
نویسندگان
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