کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565906 1128069 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test
چکیده انگلیسی

It was previously shown that the acute administration of zinc chloride elicits an antidepressant-like effect in the mouse forced swimming test (FST). We have also shown that the activation of adenosine A1 and A2A receptors produces an antidepressant-like effect in FST. Thus, this study investigated the involvement of adenosine receptors in the antidepressant-like effect of zinc in the FST. The antidepressant-like effect of ZnCl2 (30 mg/kg, i.p.) in the FST was prevented by the pretreatment of animals with caffeine (3 mg/kg, i.p., a non-selective adenosine receptor antagonist), DPCPX (2 mg/kg, i.p., a selective adenosine A1 receptor antagonist) or ZM241385 (1 mg/kg, i.p., a selective adenosine A2A receptor antagonist), administered at doses that per se produced no anti-immobility effect. Moreover, the treatment of mice with CHA (0.05 mg/kg, i.p., a selective adenosine A1 receptor agonist), DPMA (0.1 mg/kg, i.p., a selective adenosine A2A receptor agonist) or dipyridamole (0.1 µg/site, i.c.v., an adenosine transporter inhibitor) was able to potentiate the action of sub-effective doses of ZnCl2. Taken together, the results suggest that the antidepressant-like effect of zinc in the mouse FST might involve a direct or indirect activation of adenosine A1 and A2A receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 4, 15 May 2008, Pages 994–999
نویسندگان
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