کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566076 | 1128073 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetics of Lesch's typology of alcoholism
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کلمات کلیدی
DRD2INS5HTTN-methyl-d-aspartic acidCOMTCatechol-O-methyltransferaseNMDAHWEDATVNTRICD-10Insertion - افزودنAlcoholism - الکلیسمDopamine transporter - انتقال دهنده دوپامینHardy–Weinberg equilibrium - تعادل هاردی-وینبرگVariable number of tandem repeats - تعداد متغیر تکرارهای tandembase pair - جفت پایهdeletion - حذفDEL - دلDopamine - دوپامینval - ساعتSerotonin - سروتونینInternational Classification of Diseases, 10th Revision - طبقه بندی بین المللی بیماری ها، ویرایش دهمMethionine - متیونینMET - ملاقات کردhomovanillic acid - هومووانیلیک اسیدValine - والینpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازHVA - چهGenetics - ژنتیکdopamine D2 receptor - گیرنده دوپامین D2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
It is widely accepted that dopamine and serotonin (5-HT) neurotransmission can be critically involved in the development of alcohol abuse and alcohol dependence. Lesch's typology of alcoholism has been gaining increasing popularity as it qualitatively differentiates patients into different treatment response subgroups. The aim of the present study was to evaluate a possible genetic background of Lesch's typology with special emphasis placed on dopamine- and serotonin-related genes. 122 alcoholics (the mean age: 35 ± 9 years) were investigated. According to Lesch's typology, 58 patients were of type I, 36 patients of type II, 11 patients of type III, and 17 patients of type IV. Alcohol drinking and family history was assessed by means of a structured interview, based on the Semi-Structured Assessment for the Genetics of Alcoholism. 150 control subjects without psychiatric disorders were also recruited. The control group was ethnically-, age- and gender-matched to the patients. The DRD2 TaqIA, exon 8, and promoter -141C ins/del polymorphisms as well as COMT Val158Met, 5HTT 44 bp del in promoter, and DAT 40 bp VNTR polymorphisms were detected by means of PCR. No significant differences were observed when the whole group of alcoholics and the controls were compared. Similarly, there were no differences between either the Lesch type I or type II alcoholics and the control subjects. No significant differences were observed between type I and type II alcoholics. Alleles frequencies were not calculated for the Lesch type III and type IV alcoholics since the number of patients was too small. The present results argue against any major role of the investigated polymorphisms in either Lesch type I or type II alcoholism. More comprehensive studies are needed to define the role of the investigated polymorphisms in Lesch type III and type IV alcoholism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 2, 15 February 2008, Pages 423-427
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 2, 15 February 2008, Pages 423-427
نویسندگان
Jerzy Samochowiec, Jolanta Kucharska-Mazur, Anna Grzywacz, Justyna Pelka-Wysiecka, Monika Mak, Agnieszka Samochowiec, Przemyslaw Bienkowski,