کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566325 | 1128080 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Striatal and nigral COX-2 expression after chronic typical and atypical neuroleptic administration in rats Striatal and nigral COX-2 expression after chronic typical and atypical neuroleptic administration in rats](/preview/png/2566325.png)
Haloperidol, but not clozapine, induces dopaminergic nigrostriatal degeneration. However, the mechanisms by which haloperidol causes neurotoxicity are not fully understood.An increase in cyclooxygenase-2 (COX-2) expression has been observed correlated with nigrostriatal degeneration. We investigated the modifications of striatal and nigral COX-2 expression induced by chronic haloperidol and clozapine administration. Rats were treated for 21 days with: haloperidol (1 mg/kg), clozapine (1 mg/kg) or saline. No significant differences were observed in striatal and nigral COX-2 expression between haloperidol and clozapine-treated animals.This observation might suggest that nigral COX-2 expression is not the underlying mechanisms involved in haloperidol-induced dopaminergic neurodegeneration.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 3, 13 April 2007, Pages 678–682