کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566339 1128080 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nitric oxide mediates cardiovascular symptoms in alcohol withdrawal
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Nitric oxide mediates cardiovascular symptoms in alcohol withdrawal
چکیده انگلیسی

We studied whether nitric oxide is involved in cardiovascular symptoms in alcohol withdrawal. Cardiovascular effects of isosorbide dinitrate (ISDN; 20 mg sublingually), a nitric oxide donor were compared in 21 alcohol-dependent subjects during alcohol withdrawal (n = 11) on days 1, 2, 3, and 10 to those during remission (n = 10; duration = 60.7 ± 10.5 days). Cardiovascular parameters were measured non-invasively. The levels of systolic and diastolic blood pressure, total peripheral resistance were significantly higher in patients with withdrawal than in remission. Same cardiovascular parameters showed different response to ISDN during withdrawal when compared to remission. The differences were largest during the initial phase (1–2 days) of withdrawal. Nitric oxide may mediate at least some cardiovascular symptoms in withdrawal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 3, 13 April 2007, Pages 761–765
نویسندگان
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