کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2566481 | 1128084 | 2006 | 5 صفحه PDF | دانلود رایگان |

ObjectiveThe aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain.MethodsRats were given either a single (acute) or a series of eight (chronic) ECS. Brain regions were isolated and levels of glial fibrillary acidic protein (GFAP) in the brain tissue (cortex, hippocampus, and cerebellum) were assessed using an enzyme-linked immunosorbent assay (ELISA).ResultsWe showed that GFAP expression is reduced in the hippocampus within 48 h and 7 days after acute ECS. GFAP levels are increased in the cerebellum immediately after acute and chronic ECS. No changes were observed in the cortex.ConclusionsOur findings showed a differential effect of acute and chronic ECS in the astroglial response in the brain of rats.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 4, June 2006, Pages 663–667