کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566771 | 1128096 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of escitalopram on ethanol withdrawal syndrome in rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
SSRIsrat(s) - رت (ها)SERT - سختEthanol withdrawal syndrome - سندرم برداشتن اتانولselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیSelective serotonin reuptake inhibitors (SSRIs) - مهار کننده های بازجذب سروتونین انتخابی (SSRIs)Escitalopram - همزمان escitalopramEthanol dependence - وابستگی اتانول
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study was designed to investigate the effects of escitalopram, a selective serotonin reuptake inhibitor, on ethanol withdrawal syndrome in rats. Adult male Wistar rats (266-278Â g) were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21Â days. Control rats were pair fed with an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Escitalopram (2.5, 5 and 10Â mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After the second and sixth hours of ethanol withdrawal, rats were observed for 5Â min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, wet dog shakes, tremors and audiogenic seizures were recorded or rated. A second series of injections was given 30Â min before sixth hour of withdrawal test. Effects of escitalopram on the locomotor activities of the naïve (no ethanol-dependent) rats were also evaluated. Escitalopram (5Â mg/kg) reduced the increased stereotyped behaviors at the sixth hour of ethanol withdrawal. It inhibited tremors at the second hour of ethanol withdrawal at doses of 5 and 10Â mg/kg. Escitalopram (2.5 and 5Â mg/kg) also produced some significant attenuations in the incidence of wet dog shakes at the second and sixth hours of the observation period. It was found ineffective on locomotor hyperactivity, agitation and audiogenic seizures. Escitalopram (2.5 and 5Â mg/kg) did not cause any significant effect on locomotor activities of the naïve rats. Our results suggest that acute escitalopram treatment has some limited beneficial effects on ethanol withdrawal syndrome in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 6, 30 August 2006, Pages 1027-1032
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 6, 30 August 2006, Pages 1027-1032
نویسندگان
Esra SaÄlam, Hakan Kayir, Turgay Ãelik, Tayfun Uzbay,