کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566777 | 1128096 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Switching to risperidone after unsuccessful treatment of olanzapine in the first-episode schizophrenia: An open trial
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Switching to risperidone after unsuccessful treatment of olanzapine in the first-episode schizophrenia: An open trial Switching to risperidone after unsuccessful treatment of olanzapine in the first-episode schizophrenia: An open trial](/preview/png/2566777.png)
چکیده انگلیسی
The purpose of this study was to assess the effect of switching to risperidone in the treatment of first-episode schizophrenia who had failed to respond to an initial-prescribed antipsychotic, olanzapine. Fifty-one patients with first-episode schizophrenia after unsuccessful treatment of olanzapine (the mean (S.D.) dosage: 16.4 (4.4) mg/day) were included in this switching study. Of the 51 patients, 43 (84.3%) completed the full 12-week trial and 8 (15.7%) dropped out. The mean dosage of risperidone at the endpoint (last observation) was 3.1 (2.0) mg/day. The total scores of Brief Psychiatric Rating Scales (BPRS) were significantly reduced from baseline to endpoint, especially in the positive and excitement factors (p < 0.001). Responder rate (at least 20% decrease in BPRS total score plus final Clinical Global Impression score of 3 or less) was 35.3%. These findings indicate that the switching to risperidone could be one of the useful treatment options in this population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 6, 30 August 2006, Pages 1067-1072
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 6, 30 August 2006, Pages 1067-1072
نویسندگان
Hitoshi Takahashi, Keizo Yoshida, Jun Ishigooka, Hisashi Higuchi,