کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566793 1128096 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation between plasma levels of glutamate, alanine and serine with severity of depression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Correlation between plasma levels of glutamate, alanine and serine with severity of depression
چکیده انگلیسی

The goal of this study was to evaluate the utility of using plasma levels of amino acids as an indicator of the severity of depression. The samples were collected from 23 depressed patients receiving antidepressant medication, and were compared to 31 healthy subjects. The plasma levels of amino acids were determined using HPLC with fluorometric detection. The severity of depression was evaluated using the Hamilton Depression Rating Scale (HAM-D) scores. Plasma levels of glutamate, glutamine, glycine and taurine were significantly increased in the depressed patients compared to the controls. Statistical analysis indicated a positive correlation between glutamate and alanine levels and HAM-D scores and a negative correlation of l-serine with HAM-D scores. The results indicate that plasma level of glutamate, alanine and l-serine could reflect the severity of depression rather than glutamine, glycine and taurine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 30, Issue 6, 30 August 2006, Pages 1155–1158
نویسندگان
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