Current and emerging imaging in relation to drug discovery in airways disease

Medical imaging has been increasingly used in respiratory research due to the rapid and ongoing development of medical technology. Current imaging is almost entirely 3-dimensional and allows the measurement of structure and function, often both simultaneously. The information complements other measurement methods in airway research because imaging’s greatest contributions are those of topographical information, direct visualisation of functional or structural change, sampling of the whole organ (in contrast to for example bronchoscopy) and potential for in vivo imaging in a repeated, prospective nature. Medical imaging modalities of high-resolution computed tomography (HRCT), magnetic resonance imaging (MRI), ultra-high resolution imaging, positron emission computed tomography (PET) and single photon emission computed tomography (SPECT) are reviewed in relation to research in airways disease.

► Three-dimensional lung imaging modalities are useful for drug research in airways disease.
► Imaging data include airway wall, parenchymal and vascular structure and function.
► Combined modalities imaging is highly adaptable to suit airway research needs.
► Spatial information from imaging complements global lung function measurements.