کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2567497 | 1128334 | 2011 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Key role of the RhoA/Rho kinase system in pulmonary hypertension
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NFATPAECBMPR-IIPASMCHPAHIPAHPPHNPAHSMCmonocrotalineVOCC - VoccoSMA - دبیرستانRho kinase - رین کینازROK - سالSmooth muscle cell - سلول عضلانی صافPulmonary arterial smooth muscle cell - سلول عضله صاف شریانی ریهEndothelial cell - سلول های اندوتلیالPulmonary artery - شریان ریویNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهSmooth muscle α-actin - عضله صاف α-actinheritable pulmonary arterial hypertension - فشار خون شریان ریوی مجددPulmonary arterial hypertension - فشار خون شریانی ریویfasudil - فوادیلChronic hypoxia - هیپوکسی مزمنhypoxic pulmonary vasoconstriction - واژن تنفسی ریوی هیپوکسیکHPV - ویروس پایپلوم انسانیPulmonary hypertension - پرفشاری خون ریویPersistent pulmonary hypertension of the newborn - پرفشاری خون ریوی مداوم در نوزادانIdiopathic pulmonary arterial hypertension - پرفشاری خون شریانی ریوی ایدیوپاتیکVoltage-gated potassium channel - کانال پتاسیم با ولتاژvoltage-operated calcium channel - کانال کلسیم با ولتاژ
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Key role of the RhoA/Rho kinase system in pulmonary hypertension Key role of the RhoA/Rho kinase system in pulmonary hypertension](/preview/png/2567497.png)
چکیده انگلیسی
Pulmonary hypertension (PH) is a general term comprising a spectrum of pulmonary hypertensive disorders which have in common an elevation of mean pulmonary arterial pressure (mPAP). The prototypical form of the disease, termed pulmonary arterial hypertension (PAH), is a rare but lethal syndrome with a complex aetiology characterised by increased pulmonary vascular resistance (PVR) and progressive elevation of mPAP; patients generally die from heart failure. Current therapies are inadequate and median survival is less than three years. PH due to chronic hypoxia (CH) is a condition separate from PAH and is strongly associated with chronic obstructive pulmonary disease (COPD). An early event in the pathogenesis of this form of PH is hypoxic pulmonary vasoconstriction (HPV), an acute homeostatic process that maintains the ventilation-perfusion ratio during alveolar hypoxia. The mechanisms underlying HPV remain controversial, but RhoA/Rho kinase (ROK)-mediated Ca2+-sensitisation is considered important. Increasing evidence also implicates RhoA/ROK in PASMC proliferation, inflammatory cell recruitment and the regulation of cell motility, all of which are involved in the pulmonary vascular remodelling occurring in all forms of PH. ROK is therefore a potential therapeutic target in treating PH of various aetiologies. Here, we examine current concepts regarding the aetiology of PAH and also PH due to CH, focusing on the contribution that RhoA/ROK-mediated processes may make to their development and on ROK inhibitors as potential therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 24, Issue 1, February 2011, Pages 1-14
Journal: Pulmonary Pharmacology & Therapeutics - Volume 24, Issue 1, February 2011, Pages 1-14
نویسندگان
Michelle J. Connolly, Philip I. Aaronson,