کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574994 1129730 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vaccines for the prevention of cardiovascular disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Vaccines for the prevention of cardiovascular disease
چکیده انگلیسی

Atherosclerosis, especially coronary heart disease (CHD), remains a most significant global public health problem. Highly effective LDL-lowering therapies have gained widespread adoption in the United States and throughout the developed world, but therapeutic options for raising low HDL, a key independent risk factor for CHD, remain limited. We are developing a vaccine approach to raising HDL, by inducing an immune response to endogenous cholesteryl ester transfer protein (CETP), and have demonstrated proof of principle in preclinical and clinical models. This vaccine approach may offer the opportunity to address low HDL with a cost-effective semi-annual injection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 45, Issue 5, November 2006, Pages 253–257
نویسندگان
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