l-Tryptophan as an antidepressive agent in the management of treatment-resistant unipolar depression in borderline personality disorder: Three case reports

A narrative of three case reports is used to illustrate the use of l-tryptophan as an adjuvant and stand-alone antidepressive agent in treatment-resistant unipolar depression with comorbidity of borderline personality disorder and a history of self-mutilation and suicide attempts. Rationale, results and some general observations as to effectiveness, tolerability and safety of this therapy are presented.