Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function

Conclusions: Although an MDRD equation may be useful for estimating GFR, the CGCrCl-Eq should still be used for drug dosage adjustments. The CGCrCl-Eq may require a slight “adjustment factor” to be applied using serum creatinine values measured by newly established assay procedures.