کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2576056 | 1561332 | 2006 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rasagiline (TVP-1012): A new selective monoamine oxidase inhibitor for Parkinson's disease
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب سالمندان و علم پیری شناسی
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![عکس صفحه اول مقاله: Rasagiline (TVP-1012): A new selective monoamine oxidase inhibitor for Parkinson's disease Rasagiline (TVP-1012): A new selective monoamine oxidase inhibitor for Parkinson's disease](/preview/png/2576056.png)
چکیده انگلیسی
Despite the well-documented selectivity of rasagiline, the manufacturer recommends virtually all of the dietary (vis-Ã -vis tyramine) and drug restrictions of the nonselective MAO inhibitors. Although useful, selective MAO-B inhibitors have a limited role in Parkinson's disease. Of greater interest is the potential neuroprotective effect of rasagiline and its major metabolite, 1(R)-aminoindan, which may have great utility in a wide variety of neurodegenerative disorders of aging. In addition, bifunctional molecules combining selective MAO-B inhibition (based on the active moiety of rasagiline) with acetylcholinesterase inhibition or iron chelation may eventually be useful in Alzheimer's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Geriatric Pharmacotherapy - Volume 4, Issue 4, December 2006, Pages 330-346
Journal: The American Journal of Geriatric Pharmacotherapy - Volume 4, Issue 4, December 2006, Pages 330-346
نویسندگان
PharmD Guay,