کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2576102 | 1561334 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tolerability of atorvastatin in a population aged â¥65 years: A retrospective pooled analysis of results from fifty randomized clinical trials
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب سالمندان و علم پیری شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tolerability of atorvastatin in a population aged â¥65 years: A retrospective pooled analysis of results from fifty randomized clinical trials Tolerability of atorvastatin in a population aged â¥65 years: A retrospective pooled analysis of results from fifty randomized clinical trials](/preview/png/2576102.png)
چکیده انگلیسی
This pooled analysis of 50 published and unpublished studies in elderly patients found that the overall prevalences of AEs did not appear to increase with dose and appeared comparable to that observed with placebo. Although the prevalences of ALT/AST elevations appeared slightly higher in the 80-mg/d group (3.2% vs â¤0.9% in all other groups), specific musculoskeletal and hepatic AEs were rare (â¤3.0%). The rates of discontinuation appeared comparable between all 4 doses of atorvastatin and placebo. The results of this analysis support the favorable safety profile of atorvastatin across the full dose range in patients aged â¥65 years.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Geriatric Pharmacotherapy - Volume 4, Issue 2, June 2006, Pages 112-122
Journal: The American Journal of Geriatric Pharmacotherapy - Volume 4, Issue 2, June 2006, Pages 112-122
نویسندگان
DDS, MD Hey-Hadavi, MD Kuntze, PhD Luo, PharmD Silverman, PharmD Pittman, MD LePetri,