کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2580443 1561622 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy
چکیده انگلیسی


• Ellagic acid significantly reduced hyperglycemia and insulin resistance in type-2 diabetic male Wistar rats.
• Ellagic acid protected renal cells in type-2 diabetic rats from oxidative stress and inflammation.
• Ellagic acid attenuated diabetic nephropathy by reducing the expression of NF-κB, thereby preventing its downstream effect.

Diabetic nephropathy (DN) is a serious complication confronted by diabetic patients. Available data indicate that the development of DN is linked to inflammation. In this context, nuclear factor-kappa B (NF-κB) has received much attention. Ellagic acid (2,3,7,8-tetrahydroxy-chromeno[5,4,3-cde]chromene-5,10-dione), found abundantly in plant extracts and fruits, possesses numerous medicinal properties. We investigated the nephroprotective effects of oral treatment of ellagic acid in high fat diet/low dose streptozotocin (HFD/STZ)-induced type 2 diabetic Wistar albino rats. Ellagic acid treatment for 16 weeks post induction of diabetes significantly attenuated renal dysfunction and oxidative stress. Ellagic acid significantly inhibited the renal NF-кB activation. Moreover, ellagic acid significantly lowered renal pathology and suppressed transforming growth factor-beta (TGF-β) and fibronectin expressions in renal tissues. Ellagic acid also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1β), IL-6 and tumor necrosis factor-alpha (TNF-α). In cultured rat NRK 52E proximal tubular epithelial cells, ellagic acid treatment inhibited high glucose-induced activation of NF-κB and pro-inflammatory cytokine synthesis. These results suggest that ellagic acid exhibited renal protective effect in diabetic rats partly through antihyperglycemia which was accompanied by attenuation of inflammatory processes via inhibition of NF-κB pathway.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 219, 5 August 2014, Pages 64–75
نویسندگان
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