Effect of several analogs of 2,4,6-triphenyldioxane-1,3 on CYP2B induction in mouse liver

► Four TPD analogs demonstrated dose-dependent induction of mouse CYP2B. ► CisTPD and transTPD failed to induce CYP2B in mouse livers. ► Compound-specific CYP2B induction by TPD analogs occurs through gene activation. ► Compounds stimulate the recruitment of CAR to its binding site on cyp2b10 promoter.