کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2581572 | 1561653 | 2008 | 4 صفحه PDF | دانلود رایگان |
We examined the sensitivity of AChE+/− mice to the amnesic effects of scopolamine and amyloid β peptide. AChE+/− and AChE+/+ littermates, tested at 5–9 weeks of age, failed to show any difference in locomotion, exploration and anxiety in the open-field test, or in-place learning in the water-maze. However, when treated with the muscarinic receptor antagonist scopolamine (0.5, 5 mg/kg s.c.) 20 min before each water-maze training session, learning impairments were observed at both doses in AChE+/+ mice, but only at the highest dose in AChE+/− mice. The central injection of Aβ25–35 peptide (9 nmol) induced learning deficits only in AChE+/+ but not in AChE+/− mice. Therefore, the hyper-activity of cholinergic systems in AChE+/− mice did not result in increased memory abilities, but prevented the deleterious effects of muscarinic blockade or amyloid toxicity.
Journal: Chemico-Biological Interactions - Volume 175, Issues 1–3, 25 September 2008, Pages 131–134