کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2581764 | 1561646 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: A preliminary analysis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: A preliminary analysis Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: A preliminary analysis](/preview/png/2581764.png)
چکیده انگلیسی
Acetylcholinesterase (AChE) (EC. 3.1.1.7) is the acetylcholine-hydrolyzing enzyme that plays an essential role on cholinergic neurotransmission at the synapses of the brain and at the neuromuscular junctions. In order to gain insight into the molecular mechanisms of neuromuscular dysfunction associated with AChE deficiency, we have compared the RNA expression profiles of the muscles of AChE knockout mice with those of the wild-type siblings. Total RNA from the leg muscle of the mice of the wild-type and the AChE nullizygous mice were subjected to microarray analyses with Affymetrix GeneChip® Mouse Gene 1.0 ST Array. The pair-wise comparison of gene expression levels of the 28,853 mRNA transcripts showed that 303 genes were either up- or down-regulated by more than 2.0 folds in the AChE knockout mice. The interaction study of these differentially regulated genes indicated that some of these genes are clustered in biological functions that are related to lipid metabolism and the skeletal-muscular functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 187, Issues 1â3, 6 September 2010, Pages 120-123
Journal: Chemico-Biological Interactions - Volume 187, Issues 1â3, 6 September 2010, Pages 120-123
نویسندگان
Huang-Quan Lin, Roy Choi, Kam-Leung Chan, Denis Ip, Karl Wah-keung Tsim, David Chi-cheong Wan,