کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2582415 | 1561652 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain](/preview/png/2582415.png)
چکیده انگلیسی
The present work is aimed at evaluating the protective effect of the oyster mushroom, Pleurotus ostreatus on carbon tetrachloride (CCl4)-induced toxicity in male Wistar rats. Significantly elevated mean levels (p < 0.05) of malondialdehyde (MDA) and lowered mean levels (p < 0.01) of reduced glutathione (GSH), vitamins C and E (p < 0.05) were observed in kidneys, heart and brain of rats exposed to CCl4, when compared to values in normal rats. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (Gpx) and glutathione-S-transferase (GST) revealed lower activities of these antioxidant enzymes in the kidneys, heart and brain of rats exposed to CCl4. When the extract of P. ostreatus was used to treat rats with CCl4-induced toxicity, it lowered the mean level of MDA, elevated the mean levels of GSH and of vitamins C and E and enhanced the mean activities of CAT, SOD, Gpx and GST so that the values of most of these parameters did not differ significantly from those of normal rats. Histopathological studies confirmed the toxic effects of CCl4 on other organs such as kidneys, heart and brain and also tissue protective effect of the extract of P. ostreatus. These results suggest that an extract of P. ostreatus is able to alleviate the oxidative damage caused by CCl4 in the kidneys, heart and brain of Wistar rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 176, Issues 2â3, 25 November 2008, Pages 108-120
Journal: Chemico-Biological Interactions - Volume 176, Issues 2â3, 25 November 2008, Pages 108-120
نویسندگان
T. Jayakumar, M. Sakthivel, P.A. Thomas, P. Geraldine,