کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2585852 1130883 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Palmatine attenuates d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Palmatine attenuates d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice
چکیده انگلیسی

Palmatine is an isoquinoline alkaloid from Coptis chinensis, an herbal medicine used to treat various inflammatory diseases such as gastritis, edema and dermatitis. The present study examined the cytoprotective properties of palmatine on d(+)-galactosamine (GalN)/lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were intraperitoneally given GalN (700 mg/kg)/LPS (10 μg/kg). Palmatine (25, 50, 100, and 200 mg/kg) was administered 1 h before GalN/LPS. GalN/LPS increased the mortality and serum aminotransferase activities. These increases were attenuated by palmatine. GalN/LPS increased hepatic lipid peroxidation and decreased the contents of reduced glutathione. Palmatine did not affect the lipid peroxidation and glutathione content. GalN/LPS increased the circulating levels of tumor necrosis factor (TNF)-α, interleukin-6 (IL-6) and IL-10. Palmatine prevented the increase of serum TNF-α and augmented that of serum IL-10. GalN/LPS treatment also increased the levels of TNF-α, IL-6 and IL-10 mRNA expression in liver tissue. Palmatine decreased the TNF-α mRNA expression and increased the IL-10 mRNA expression. Palmatine attenuated the apoptosis of hepatocytes, as evidenced by the TUNEL method and capase-3 analysis. Our data suggest that palmatine alleviates GalN/LPS-induced liver injury by modulating the cytokine response and inhibiting apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 1, January 2010, Pages 222–228
نویسندگان
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