کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2591519 1131813 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Memory ability and hippocampal volume in adolescents with prenatal drug exposure
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Memory ability and hippocampal volume in adolescents with prenatal drug exposure
چکیده انگلیسی

The objective of the present study was to examine the influence of prenatal drug exposure (PDE) on memory performance and supporting brain structures (i.e., hippocampus) during adolescence. To achieve this goal, declarative memory ability and hippocampal volume were examined in a well-characterized sample of 138 adolescents (76 with a history of PDE and 62 from a non-exposed comparison group recruited from the same community, mean age = 14 years). Analyses were adjusted for: age at time of the assessments, gender, IQ, prenatal exposure to alcohol and tobacco, and indices of early childhood environment (i.e., caregiver depression, potential for child abuse, and number of caregiver changes through 7 years of age). Results revealed that adolescents with a history of PDE performed worse on the California Verbal Learning Test—Child Version (CVLT-C), and story recall from the Children's Memory Scale (CMS), and had larger hippocampal volumes, even after covariate adjustment. Hippocampal volume was negatively correlated with memory performance on the CVLT-C, with lower memory scores associated with larger volumes. These findings provide support for long-term effects of PDE on memory function and point to neural mechanisms that may underlie these outcomes.


► Examined long-term effects of prenatal drug exposure (PDE) during adolescence
► PDE negatively impacted memory ability and hippocampal volume.
► Better memory ability was associated with smaller hippocampal volume.
► Findings support hypotheses that PDE has long-term effects on cognition.
► Suggest effects of PDE on memory in adolescence operate through neural mechanisms

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 34, Issue 4, July–August 2012, Pages 434–441
نویسندگان
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