کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2592656 | 1132037 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Establishing a point of departure for risk assessment using acute inhalation toxicology data Establishing a point of departure for risk assessment using acute inhalation toxicology data](/preview/png/2592656.png)
A simple method is presented for estimating a non-lethal level for inhalation toxicity studies. By reviewing 209 LC50 studies representing 96 chemicals that also reported a non-lethal level, it has been shown that taking 1/3 of the LC50 is a conservative estimate for a non-lethal exposure level. This approach was also compared to studies with LC01 and BMCL05 calculations. In the 38 studies that reported either of these values, again taking 1/3 of the LC50 provided a more conservation estimate for the non-lethal threshold. The studies included time intervals from 5 min out to 8 h and utilized multiple species such as the rat, mouse, hamster, guinea pig and dog. In all but 13 cases, taking 1/3 of the LC50 provided a more conservative estimate for a non-lethal exposure level compared to the experimentally observed value. In all but one of the 13 cases, the higher values were consequences of the selection of the exposure levels.
Journal: Regulatory Toxicology and Pharmacology - Volume 54, Issue 3, August 2009, Pages 247–255