Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line

- Dexamethasone suppresses CYP1A1 transactivation by AHR ligands in JEG-3 cells.
- RU486, a GR antagonist, abolishes the effect of dexamethasone.
- Dexamethasone stimulates degradation of AHR in JEG-3 cells.