Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase

► We investigated the kinetic interactions of a homologous series of oximes with native and cyclosarin-inhibited human AChE. ► The length of the oxime alkyl side chain was correlated with an increased affinity towards native AChE. ► The effect of the alkyl side chain on the affinity and reactivity towards phosphonylated AChE was moderate. ► In comparison to the reference oxime HI-6 all tested oximes had a lower reactivating potency.