کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599600 1133220 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase
چکیده انگلیسی
► We investigated the kinetic interactions of a homologous series of oximes with native and cyclosarin-inhibited human AChE. ► The length of the oxime alkyl side chain was correlated with an increased affinity towards native AChE. ► The effect of the alkyl side chain on the affinity and reactivity towards phosphonylated AChE was moderate. ► In comparison to the reference oxime HI-6 all tested oximes had a lower reactivating potency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 212, Issue 1, 7 July 2012, Pages 29-32
نویسندگان
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