کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2603052 | 1133805 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2(±)-7,8,3â²,4â²,5â²-pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 2(±)-7,8,3â²,4â²,5â²-pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells 2(±)-7,8,3â²,4â²,5â²-pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells](/preview/png/2603052.png)
چکیده انگلیسی
2(±)-7,8,3â²,4â²,5â²-pentamethoxyflavan (PMF), a synthetic flavan racemate, showed growth inhibitory effect on various kinds of tumor cells. The present study is to investigate the molecular mechanisms of action of PMF in human leukemia HL60 cells. Anti-proliferative effect of PMF on HL60 cells was associated with G2/M cell cycle arrest, which was mediated by regulating the expression of Cdc25C, cyclin A and p21 proteins and inhibiting the phosphorylation of Cdc2 at Thr161. PMF also induced apoptosis of HL60 cells via death receptor and mitochondria apoptotic pathways, which was characterized by DNA fragmentation, cleavage of poly (ADP-ribose) polymerase, caspase-3, caspase-8 and caspase-9, changes of Bcl-2 and Bax expression, cytochrome c release from mitochondria and a decrease in the mitochondrial membrane potential (MMP). These data suggest that PMF produces anti-tumor effect via induction of G2/M cell cycle arrest and apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 23, Issue 5, August 2009, Pages 874-879
Journal: Toxicology in Vitro - Volume 23, Issue 5, August 2009, Pages 874-879
نویسندگان
Enlong Ma, Yanchun Li, Weige Zhang, Xiaolong Wang, Wenjiao Tai, Te Li, Liang Zhang, Takashi Ikejima,