Synthesis and characterization of Schiff base complexes derived from cephradine: Fluorescence, photostability and photobiological applications

• Preparation and characterization of a new Schiff base and preparation of its Zn(II), Cu(II), Co(II) and Ni(II) complexes.
• Measuring the luminescence properties of the prepared Schiff base and its complexes.
• Studying the photostability of Schiff base, L, and its Zn(II)-L and Cu(II)-L complexes.
• Studying the photobilogical activity of cephradine, benzopyran-4-one, Schiff base, L, and all complexes.
• Studying the in vitro cytotoxicity of the Schiff base and its complexes against Hep G2-cell line.

A new Schiff base derived from the condensation of 6-formyl-7-hydroxy-5-methoxy-2-methylbenzo-pyran-4-one (benzopyran-4-one derivative) with cephradine drug (L) was prepared and characterized by elemental analyses and some spectroscopic studies. Also, Zn(II), Cu(II), Co(II) and Ni(II) complexes of that Schiff base were prepared by template reaction. Many tools of analysis such as elemental analyses, infrared, ultraviolet-visible and thermal analysis, as well as electrical conductance and magnetic susceptibility measurements were used to elucidate the structure of these complexes. The data showed that Zn(II)-L and Cu(II)-L complexes are 1:1 (M:L). The ligand was found to be monobasic bidentate. On the other hand, Ni(II)-L and Co(II)-L form binuclear complexes. All the complexes are non-electrolyte. The luminescence properties of the prepared Schiff base and its complexes were measured. The photostability of Schiff base, L, and its Zn(II)-L and Cu(II)-L complexes were also studied. The photobiological activity of cephradine, benzopyran-4-one derivative, Schiff base, L and the complexes were studied on mosquito larvae to investigate the extent of their photosensitization efficiency in controlling noxious insects using direct sunlight (larvicidal effect). In vitro cytotoxicity study of the Schiff base and its complexes against Hep G2-cell line was investigated by the MTT assay. The Schiff base, L, exhibits better activity against Hep G2 cell line than the complexes.

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