Nouveautés dans les facteurs histopronostiques des cancers du sein

The pathological analysis of a breast cancer requires a thorough macroscopic and histological examination to assess the conventional prognostic factors of size, type, grade and a careful search of vascular invasions and of lymph node infiltration. Additional immunostainings are useful to determine the estradiol and progesterone receptors content of the tumour, as well as its HER2 status and its proliferating index. E-cadherin and subtypes of cytokeratin immunostainings may help in difficult cases to precise the histological type of the tumour. A selection of new prognostic factors is also presented.