کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2821101 | 1160922 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Replication-associated purine asymmetry may contribute to strand-biased gene distribution Replication-associated purine asymmetry may contribute to strand-biased gene distribution](/preview/png/2821101.png)
Among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased. Several hypotheses explaining this strand-biased gene distribution (SGD) have been proposed, but none have been tested or supported by sufficient data analyses. In this work we have analyzed 211 prokaryotic genomes in terms of compositional strand asymmetries and the presence or absence of polC and have found that SGD correlates not only with polC, but also with purine asymmetry (PAS). Furthermore, SGD, PAS, and polC are all features associated with a group of low-GC, gram-positive bacteria (Firmicutes). We conclude that PAS is a characteristic of organisms with a heterodimeric DNA polymerase III α-subunit constituted by polC and dnaE, which may play a direct role in the maintenance of SGD.
Journal: Genomics - Volume 90, Issue 2, August 2007, Pages 186–194