کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2821448 | 1160952 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China](/preview/png/2821448.png)
In this study, we systematically screened the polymorphisms of the whole CYP2D6 gene in the populations of four different geographical locations in China, namely, Shanghai, Shantou, Shenyang, and Xi'an, using a sample of 100 subjects from each population. Forty-eight different polymorphisms were detected as well as 12 novel ones. One novel nonsynonymous SNP was detected, and one novel intronic SNP was revealed that might inactivate a cryptic donor site 392 nucleotides downstream of the exon 6 natural donor site. In addition, the frequencies of some polymorphisms and alleles demonstrated significant differences among the four populations. Linkage disequilibrium analysis and tag SNP selection were performed separately for each population. Haplotypes were analyzed within the selected tag SNPs. Tag SNP selection and haplotype distributions showed differences across the four populations. This is the first large-scale study to analyze polymorphisms systematically across the whole CYP2D6 gene in the Chinese Han population.
Journal: Genomics - Volume 92, Issue 3, September 2008, Pages 152–158