کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2821748 1161001 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A wide-range phylogenetic analysis of Zic proteins: Implications for correlations between protein structure conservation and body plan complexity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
A wide-range phylogenetic analysis of Zic proteins: Implications for correlations between protein structure conservation and body plan complexity
چکیده انگلیسی

We compared Zic homologues from a wide range of animals. Striking conservation was found in the zinc finger domains, in which an exon–intron boundary has been kept in all bilateralians but not cnidarians, suggesting that all of the bilateralian Zic genes are derived from a single gene in a bilateralian ancestor. There were additional conserved amino acid sequences, ZOC and ZF-NC. Combined analysis of the zinc finger, ZOC, and ZF-NC revealed the presence of two classes of Zic, based on the degree of protein structure conservation. The “conserved” class includes Zic proteins from the Arthropoda, Mollusca, Annelida, Echinodermata, and Chordata (vertebrates and cephalochordates), whereas the “diverged” class contains those from the Platyhelminthes, Cnidaria, Nematoda, and Chordata (urochordates). The result indicates that the ancestral bilateralian Zic protein had already acquired an entire set of conserved domains, but that this was lost and diverged in the platyhelminthes, nematodes, and urochordates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 87, Issue 6, June 2006, Pages 783–792
نویسندگان
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