کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2822623 1161302 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting sRNAs and Their Targets in Bacteria
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Predicting sRNAs and Their Targets in Bacteria
چکیده انگلیسی

Bacterial small RNAs (sRNAs) are an emerging class of regulatory RNAs of about 40–500 nucleotides in length and, by binding to their target mRNAs or proteins, get involved in many biological processes such as sensing environmental changes and regulating gene expression. Thus, identification of bacterial sRNAs and their targets has become an important part of sRNA biology. Current strategies for discovery of sRNAs and their targets usually involve bioinformatics prediction followed by experimental validation, emphasizing a key role for bioinformatics prediction. Here, therefore, we provided an overview on prediction methods, focusing on the merits and limitations of each class of models. Finally, we will present our thinking on developing related bioinformatics models in future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics, Proteomics & Bioinformatics - Volume 10, Issue 5, October 2012, Pages 276–284
نویسندگان
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