کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2822865 | 1570158 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genomic constellation and evolution of Ghanaian G2P[4] rotavirus strains from a global perspective
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کلمات کلیدی
MCMCBICBayesian Evolutionary Analysis Sampling TreesRVANSPG2P[4]TMRCANSP4RNA polymerase - آرانای پلیمراز، RNA پلیمراز Interferon antagonist - آنتاگونیست اینترفرونEnterotoxin - انتروتوکسینReassortment - بازنشستگیBEAST - بیmolecular evolutionary genetics analysis - تجزیه و تحلیل ژنتیک تکامل مولکولیRotavirus - روتاویروس Rotavirus A - روتاویروس AMarkov chain Monte Carlo - زنجیره مارکف مونت کارلوGhana - غناPhosphoprotein - فسفوپروتئینBayesian information criterion - معیار اطلاعات بیزیTranslation regulation - مقررات ترجمهMEGA - مگاNon-structural protein - پروتئین غیر ساختاریViral protein - پروتئین ویروسیcore shell - پوسته اصلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genomic constellation and evolution of Ghanaian G2P[4] rotavirus strains from a global perspective Genomic constellation and evolution of Ghanaian G2P[4] rotavirus strains from a global perspective](/preview/png/2822865.png)
چکیده انگلیسی
Understanding of the genetic diversity and evolution of Rotavirus A (RVA) strains, a common cause of severe diarrhoea in children, needs to be based on the analysis at the whole genome level in the vaccine era. This study sequenced the whole genomes of six representative G2P[4] strains detected in Ghana from 2008 to 2013, and analysed them phylogenetically with a global collection of G2P[4] strains and African non-G2P[4] DS-1-like strains. The genotype constellation of the study strains was G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Strains from the same season were highly identical across the whole genome while strains from different seasons were more divergent from each other. The VP7, VP4, VP2, NSP1, and NSP5 genes belonged to lineage IVa; the VP6, VP1, NSP2, and NSP3 genes belonged to lineage V, and all these genes evolved in the same fashion as the global strains. In the NSP4 gene, lineages V (2008) and X (2009) were replaced by VI (2012/2013) whereas in the VP3 gene, lineage V (2008/2009) was replaced by VII (2012/2013) and these replacements coincided with the vaccine introduction period (2012). The evolutionary rate of the NSP4 gene was 1.2 Ã 10â 3 substitutions/site/year and was rather comparable to that of the remaining 10 genes. The multiple NSP4 lineages were explained by intra-genotype reassortment with co-circulating African human DS-1-like strains bearing G2[6], G3P[6], G6[6] and G8. There was no explicit evidence of the contribution of animal RVA strains to the genome of the Ghanaian G2P[4] strains. In summary, this study revealed the dynamic evolution of the G2P[4] strains through intra-genotype reassortment events leading to African specific lineages such IX and X in the NSP4 gene. So far, there was no evidence of a recent direct involvement of animal RVA genes in the genome diversity of African G2P[4] strains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 45, November 2016, Pages 122-131
Journal: Infection, Genetics and Evolution - Volume 45, November 2016, Pages 122-131
نویسندگان
Chantal Ama Agbemabiese, Toyoko Nakagomi, Yen Hai Doan, Loan Phuong Do, Susan Damanka, George E. Armah, Osamu Nakagomi,