کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2889838 1574393 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Digoxin therapy: A persisting interest despite contrary winds
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Digoxin therapy: A persisting interest despite contrary winds
چکیده انگلیسی

Digoxin therapy is used to treat heart failure patients for more than 200 years. However, absence of effect on overall mortality found in the DIG study associated with frequent adverse effects due to overdosing in elderly patients with impaired renal function finally persuaded medical opinion to the weak interest of digoxin in chronic heart failure. Its image of old-fashioned drug in the mind of young cardiology generations appears widely distorted, and suffers from the absence of promotion by pharmaceutical industry, given a very low cost and a rapid arrival onto the generic market. Yet, regarding strict data from the literature, it remains a lot of positive factors in favor of the interest for digoxin: reduction of morbidity, reduction of mortality at low serum concentration < 1.0 ng/ml, very low cost with favorable cost-effectiveness ratio. This article challenges some arguments for defending digoxin as another first-line therapy as well as ACE inhibitors and beta-blockers in the treatment of chronic heart failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Cardiovascular Diseases - Volume 103, Issue 5, May 2010, Pages 281–284
نویسندگان
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