کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2938193 1176927 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LA Volumes and Reservoir Function Are Associated With Subclinical Cerebrovascular Disease : The CABL (Cardiovascular Abnormalities and Brain Lesions) Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
LA Volumes and Reservoir Function Are Associated With Subclinical Cerebrovascular Disease : The CABL (Cardiovascular Abnormalities and Brain Lesions) Study
چکیده انگلیسی

ObjectivesThe purpose of this study was to assess the relationship of left atrial (LA) phasic volumes and LA reservoir function with subclinical cerebrovascular disease in a stroke-free community-based cohort.BackgroundAn increase in LA size is associated with cardiovascular events including stroke. However, it is not known whether LA phasic volumes and reservoir function are associated with subclinical cerebrovascular disease.MethodsThe LA minimum (LAVmin) and maximum (LAVmax) volumes, and LA reservoir function, measured as total emptying volume (LAEV) and total emptying fraction (LAEF), were assessed by real-time 3-dimensional echocardiography in 455 stroke-free participants from the community-based CABL (Cardiovascular Abnormalities and Brain Lesions) study. Subclinical cerebrovascular disease was assessed as silent brain infarcts (SBI) and white matter hyperintensity volume (WMHV) by brain magnetic resonance imaging.ResultsPrevalence of SBI was 15.4%; mean WMHV was 0.66 ± 0.92%. Participants with SBI showed greater LAVmin (17.1 ± 9.3 ml/m2 vs. 12.5 ± 5.6 ml/m2, p < 0.01) and LAVmax (26.6 ± 8.8 ml/m2 vs. 23.3 ± 7.0 ml/m2, p < 0.01) compared to those without SBI. The LAEV (9.5 ± 3.4 ml/m2 vs. 10.8 ± 3.9 ml/m2, p < 0.01) and LAEF (38.7 ± 14.7% vs. 47.0 ± 11.9%, p < 0.01) were also reduced in participants with SBI. In univariate analyses, greater LA volumes and smaller reservoir function were significantly associated with greater WMHV. In multivariate analyses, LAVmin remained significantly associated with SBI (adjusted odds ratio per SD increase: 1.37, 95% confidence interval: 1.04 to 1.80, p < 0.05) and with WMHV (β = 0.12, p < 0.01), whereas LAVmax was not independently associated with either. Smaller LAEF was independently associated with SBI (adjusted odds ratio: 0.67, 95% confidence interval: 0.50 to 0.90, p < 0.01) and WMHV (β = −0.09, p < 0.05).ConclusionsGreater LA volumes and reduced LA reservoir function are associated with subclinical cerebrovascular disease detected by brain magnetic resonance imaging in subjects without history of stroke. In particular, LAVmin and LAEF are more strongly associated with SBI and WMHV than the more commonly measured LAVmax, and their relationship with subclinical brain lesions is independent of other cardiovascular risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: JACC: Cardiovascular Imaging - Volume 6, Issue 3, March 2013, Pages 313–323
نویسندگان
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