کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2963887 1178599 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A case of chemoradiotherapy-associated cardiotoxicity that developed into acute heart failure with progressive subendocardial fibrosis
ترجمه فارسی عنوان
یک مورد سمیت قلبی مرتبط با شیمی درمانی که به نارسایی حاد قلبی با فیبروز پیشرونده سوندنوکاردال
کلمات کلیدی
سرطان پستان، سمیت قلبی، شیمی درمانی، فیبروز سوندوکارد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

We describe the case of a 61-year-old Japanese woman who developed acute heart failure 5 years after chemoradiotherapy for breast cancer. The patient received less than the cardiotoxic dose of docetaxel, epirubicin, cyclophosphamide, and fluorouracil and experienced no cardiovascular complications in the 5 years between the onset of chemoradiotherapy and the onset of acute heart failure. Cardiac catheterization was performed and elevation of end diastolic pressure of both ventricles was observed. Endomyocardial biopsy showed progressive replacement fibrosis in the subendocardium. Normal thickness of the right endocardium is <20 μm. Surprisingly, our patient had a fibrous subendocardium that was 100–200 μm thick. Ultrastructural abnormalities similar to those observed in anthracycline cardiotoxicity were evident on electron micrographs. This case report demonstrates the unique pathophysiology of heart failure in a patient who received less than the cardiotoxic dose of antineoplastic agents. Recent protocols have decreased the dosage of cardiotoxic agents; however, even these reduced doses might not be safe for all Japanese individuals and may cause subclinical cardiovascular damage and late-onset heart failure. Clinicians should monitor cancer survivors carefully, even if antineoplastic agents were administered under the cardiotoxic dose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiology Cases - Volume 10, Issue 3, September 2014, Pages 115–120
نویسندگان
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