کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2966943 | 1178822 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes Association between apolipoprotein E polymorphism, lipids, and coronary artery disease in Tunisian type 2 diabetes](/preview/png/2966943.png)
BackgroundThe relationship between apolipoprotein E (ApoE) polymorphism, fasting lipid parameters, and coronary artery disease (CAD) is controversial.MethodsWe studied this relationship, for the first time, in Tunisian type 2 diabetic patients. The studied population comprised 157 type 2 diabetic patients (145 of them were not on any lipid-lowering drugs). Fasting lipids were measured by enzymatic methods and ApoE genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism.ResultsOur results showed that the alleles E2, E3, and E4 were found in 4%, 88%, and 8% of patients, respectively. In the total type 2 diabetic population, no association was found between ApoE polymorphism, lipid parameters, and CAD. However, the E4 allele was associated with elevated low-density lipoprotein cholesterol concentration and with CAD in type 2 diabetic men.ConclusionThe effect of ApoE polymorphism on CAD is gender-dependent in the Tunisian type 2 diabetic population. ApoE 4 allele may enhance atherogenesis indirectly by a strong effect on low-density lipoprotein cholesterol.
Journal: Journal of Clinical Lipidology - Volume 2, Issue 5, October 2008, Pages 360–364