کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
29719 44431 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature
ترجمه فارسی عنوان
فلورسانس در جراحی مغز و اعصاب: استفاده تشخیصی و درمانی آن. مرور ادبیات
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• 5-ALA-fluorescence guided resection improves overall survival.
• 5-ALA in photodynamic therapy is a promising treatment option.
• Intraoperative ICG angiography might be of value for vascular pathologies.
• Fluorescein fluorescence is less specific for pathologies.

Fluorescent agents, e.g. 5-aminolevulinic acid (5-ALA), fluorescein and indocyanine green (ICG) are in common use in neurosurgery for tumor resection and neurovascular surgery. Protoporphyrine IX (PPIX) as major metabolite of 5-ALA is a strong fluorescent substance accumulated within malignant glioma tissue and a very sensitive and specific tool for visualizing high grade glioma tissue during surgery. Furthermore, 5-ALA or rather PPIX also offers an intratumoral therapeutic option stimulated by laser light in specific wavelength. Fluorescein was demonstrated to show similar fluorescent reactions in neurosurgery, but is controversial in its use, especially in high grade tumor surgery. Intraoperative angiography during resection of arterio-venous malformations, extracranial–intracranial-bypass or aneurysm surgery is supported by ICG fluorescence. Generally ICG will provide beneficial information for both, exposure of the pathology and illustration of healthy structures. This manuscript shows an overview of the literature focussing fluorescence in neurosurgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 148, July 2015, Pages 302–309
نویسندگان
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