کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
29739 44434 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photoaging and chronological aging profile: Understanding oxidation of the skin
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Photoaging and chronological aging profile: Understanding oxidation of the skin
چکیده انگلیسی

The impact of chronological aging and photoaging on the skin is particularly concerning, especially when oxidative stress is involved. This article provides evidence of quantitative and qualitative differences in the oxidative stress generated by chronological aging and photoaging of the skin in HRS/J hairless mice. Analysis of the results revealed an increase in lipid peroxides as the skin gets older and in photoaged skin (10.086 ± 0.70 η MDA/mg and 14.303 ± 1.81 η MDA/mg protein, respectively), although protein oxidation was only verified in chronological aged skin (15.449 ± 0.99 η protein/mg protein). The difference between both skin types is the decay in the capacity of lipid membrane turnover revealed by the dislocation of older skin to the left in the chemiluminescence curve. Imbalance between antioxidant and oxidation processes was verified by the decrease in total antioxidant capacity of chronological and photoaged skins. Although superoxide dismutase remained unchanged, catalase increased in the 18 and 48-week-old skin groups and decreased in irradiated mice, demonstrating that neither enzyme is a good parameter to determine oxidative stress. The differences observed between chronological and photoaging skin represent a potential new approach to understanding the phenomenon of skin aging and a new target for therapeutic intervention.

Research highlights
► We used the hairless HRS/J hairless mouse model which is adequate for this study.
► Oxidative stress is predominant in photoaging.
► Lipid membrane turn over decay is present in chronological aging.
► Different cellular redox response towards both aging processes.
► Antioxidant enzymes are not good parameters to determine oxidative stress and cell.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 103, Issue 2, 3 May 2011, Pages 93–97
نویسندگان
, , , , ,