کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2998763 | 1180259 | 2015 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Testosterone Therapy and Cardiovascular Risk: Advances and Controversies
ترجمه فارسی عنوان
درمان تستوسترون و خطر قلب و عروق: پیشرفت و اختلاف نظر
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کلمات کلیدی
SHBGFDAHDLMACEHbA1cPDE5IChFRCThigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاRandomized controlled trial - آزمایش تصادفی کنترل شدهMyocardial infarction - آنفارکتوس میوکاردcoronary artery disease - بیماری عروق کرونرtestosterone - تستوسترونmajor adverse cardiac events - حوادث مهم قلبی عروقیFood and Drug Administration - سازمان غذا و داروCAD - طراحی به کمک رایانه یا کَدphosphodiesterase type 5 inhibitor - فسفودی استراز 5 نوع مهار کنندهcardiovascular - قلبی عروقیcongestive heart failure - نارسایی احتقانی قلبhazard ratio - نسبت خطرHemoglobin A1c - هموگلوبین A1csex hormone–binding globulin - هورمون جنسی مرتبط گلوبولین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Two recent studies raised new concerns regarding cardiovascular (CV) risks with testosterone (T) therapy. This article reviews those studies as well as the extensive literature on T and CV risks. A MEDLINE search was performed for the years 1940 to August 2014 using the following key words: testosterone, androgens, human, male, cardiovascular, stroke, cerebrovascular accident, myocardial infarction, heart attack, death, and mortality. The weight and direction of evidence was evaluated and level of evidence (LOE) assigned. Only 4 articles were identified that suggested increased CV risks with T prescriptions: 2 retrospective analyses with serious methodological limitations, 1 placebo-controlled trial with few major adverse cardiac events, and 1 meta-analysis that included questionable studies and events. In contrast, several dozen studies have reported a beneficial effect of normal T levels on CV risks and mortality. Mortality and incident coronary artery disease are inversely associated with serum T concentrations (LOE IIa), as is severity of coronary artery disease (LOE IIa). Testosterone therapy is associated with reduced obesity, fat mass, and waist circumference (LOE Ib) and also improves glycemic control (LOE IIa). Mortality was reduced with T therapy in 2 retrospective studies. Several RCTs in men with coronary artery disease or heart failure reported improved function in men who received T compared with placebo. The largest meta-analysis to date revealed no increase in CV risks in men who received T and reduced CV risk among those with metabolic disease. In summary, there is no convincing evidence of increased CV risks with T therapy. On the contrary, there appears to be a strong beneficial relationship between normal T and CV health that has not yet been widely appreciated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 90, Issue 2, February 2015, Pages 224-251
Journal: Mayo Clinic Proceedings - Volume 90, Issue 2, February 2015, Pages 224-251
نویسندگان
Abraham MD, Martin M. MD, Monica MSc, Andre T. MD, Mohit MD, Abdulmaged M. PhD,