کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3014810 | 1181911 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
El efecto de la inyección transendocárdica de células mononucleadas de médula ósea es diferente en pacientes diabéticos y en no diabéticos: hallazgos derivados de estudios clÃnicos prospectivos en pacientes «sin opción»
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: El efecto de la inyección transendocárdica de células mononucleadas de médula ósea es diferente en pacientes diabéticos y en no diabéticos: hallazgos derivados de estudios clÃnicos prospectivos en pacientes «sin opción» El efecto de la inyección transendocárdica de células mononucleadas de médula ósea es diferente en pacientes diabéticos y en no diabéticos: hallazgos derivados de estudios clÃnicos prospectivos en pacientes «sin opción»](/preview/png/3014810.png)
چکیده انگلیسی
Whether stem cell treatment has the same effect in diabetics and nondiabetics is unknown. To compare outcomes in these two groups, we analyzed data from 26 consecutive patients with chronic ischemic cardiomyopathy who were taking part in two clinical trials. Revascularization was not an option for these patients and they were treated with bone marrow mononuclear cells (BMMNCs). Patients underwent NOGA electromechanical mapping to identify viable myocardium (i.e., with a unipolar voltage â¥Â 6.9 mV), after which they received a mean of 28.5±4.7Ã106 BMMNCs. Patients were followed up at 6 months. In nondiabetics, there was a significant decrease in endsystolic volume between baseline and 6-month follow-up. In addition, New York Heart Association (NYHA) functional class decreased significantly (P=.04) from 3.0 (1.75-3.0) to 1.0 (1.0-2.0), the Canadian Cardiovascular Society angina score (CCSAS) improved significantly (P=.04) from 3.0 (2.0-4.0) to 1.0 (1.0-1.5), and oxygen uptake increased significantly (P=.04) from 16.4 (13.1-21.5) to 24.5 (17.3- 29.2) ml/kg/min. These changes were not observed in diabetic patients. This is the first clinical study to show that BMMNC injection could have a smaller effect in diabetics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Española de CardiologÃa - Volume 61, Issue 6, June 2008, Pages 635-639
Journal: Revista Española de CardiologÃa - Volume 61, Issue 6, June 2008, Pages 635-639
نویسندگان
Pilar Jiménez-Quevedo, Guillherme V. Silva, Ricardo Sanz-Ruiz, Edie M. Oliveira, Marlos R. Fernandes, Franca Angeli, James T. Willerson, Hans F. Dohmann, Emerson C. Perin,