کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
30186 44463 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life
چکیده انگلیسی


• An azobenzene derivative-liposome as sunscreen with longer UV protection and longer shelf life.
• Structure of CDBA-liposome is stable upon periodic UV and visible light irradiation.
• The CDBA-liposome shows protective function for both UVA and UVB in vitro.
• CDBA-liposome performs photo controlled release of encapsulated components.
• CDBA-liposome provides a longer and good UV protection in vivo with nude mouse.

Harmful effects caused by the absorption of ultraviolet (UV) light can be reduced by using sunscreens. The long-wavelength UV (UVA) and short-wavelength UV (UVB) protective effects of an azobenzene compound, 4-cholesterocarbonyl-4′-(N,N′-diethylaminobutyloxy) azobenzene (CDBA) liposomal formulation, especially its repeated photo-isomerization were evaluated in the presence of substrates such as propylene glycol and glycerol. It was indicated that periodic UV and visible light irradiation did not affect the photo-isomerization and the structure of CDBA-liposome. The stability and photo-isomerization of CDBA-liposomes were not affected by coexistence of 5% propylene glycol and 5% glycerol. CDBA-liposomes could still perform photo-controlled release of encapsulated active component when mixed with propylene glycol. Moreover, the CDBA-liposome mixed with the cream substrate showed protective function for both UVA and UVB in vitro. The in vivo tests using nude mouse confirmed that the CDBA-liposome could provide a good UV protective efficacy with longer shelf life. Therefore, CDBA-liposomes have the potential using as a new type of commercial sunscreen.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 129, 5 December 2013, Pages 78–86
نویسندگان
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