Influence of the MTHFR C677T Polymorphism on Magnetic Resonance Imaging Hyperintensity Volume and Cognition in Geriatric Depression

MTHFR genotype affects the relationship between age and WML volume where individuals who carry the 677T allele exhibit greater WML volume by age, although this relationship should be verified given the failure to replicate the finding using transformed WML volumes. Genotype was not related to GML volume, cognitive function, or presence of depression, although demographic differences could account for this negative finding.