Effects of Age and Age of Onset on Prescribed Antipsychotic Dose in Schizophrenia Spectrum Disorders: A Survey of 1,418 Patients in Japan

Our results suggested biphasic effects of age on antipsychotic dose prescribed in patients with schizophrenia spectrum disorders. The natural history of schizophrenia and physiological aging may contribute to this inverted U-shaped relationship. In addition, our results may add another evidence of distinction among EOS, LOS, and VLOS from a clinical psychopharmacological perspective.