کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3039848 1579687 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does delayed facial involvement implicate a pattern of “descending reversible paralysis” in Fisher syndrome?
ترجمه فارسی عنوان
آیا تاخیر در شکل گیری چهره یک الگوی نابسامانی فلج برگشتی را نشان می دهد؟ در سندرم فیشر؟
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


• We identified the incidence and clinical course of DFP (delayed facial palsy) in FS (Fisher syndrome).
• DFP was identified as a common (16%) and specific phenomenon in FS, as well as GBS (Guillain–Barré syndrome).
• DFP developed in a descending manner and showed a good outcome.

ObjectiveDelayed facial palsy (DFP) has often been described during the recovery stage of Fisher syndrome (FS), but the implications of DFP in FS pathophysiology have not been reported previously. The aim of this study was to identify the incidence and clinical course of DFP in FS, and to determine its clinical/pathophysiological implications in FS.MethodsAbout 71 FS patients were enrolled from seven university-based hospitals in Korea. DFP was defined with respect to new development of unilateral or bilateral facial palsies with delayed onset after either the nadir or improvement of initial neurological signs of FS.ResultsEleven of the 71 patients (16%) satisfied the definition of DFP. No other cranial palsies developed as a delayed pattern. With the exception of two patients with bulbar involvement, DFP developed after a latent period of upper-cranial neuropathies. Comparison of FS patients without and with DFP revealed no significant clinical, serological, or electrophysiological differences. All except one patient with DFP exhibited a good outcome within 1 month of follow-up.ConclusionDFP was identified as a common and specific phenomenon in FS. Nearly all cases of DFP were developed in a descending manner and were associated with a good outcome, while other cranial neuropathies developed or followed as a sequential pattern. These findings suggest the involvement of so-called “descending reversible paralysis” in the pathophysiology of FS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 135, August 2015, Pages 1–5
نویسندگان
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